Bioengineering, and notably tissue engineering, gives customised medicine a fresh perspective. Blood transfusions, bone marrow transplants, and autologous chondrocyte implantation to re-grow cartilage are just a few examples of how cells and therapies are being used to help the body heal itself.
Over 2000 clinical studies involving cell therapies, such as stem cells for ischemic heart regions, neural precursor cells for Parkinson’s illness, and oligodendrocytes derived from embryonic stem cells to heal spinal cord damage, have been paved by these techniques.Visit QC Kinetix (Westover Hills) – San Antonio Regenerative Medicine for more details.
The best way to transplant these cells is to figure out what the best mechanism is. Cell-based therapy is used to treat osteoarthritis of the knee, where cartilage and subchondral bone loss results in less fibro cartilage healing than the mechanical qualities of articular cartilage. Over 250,000 knee replacements are performed each year, with the majority of patients developing acute degenerative joint disease. Because the cells have a tendency to produce fibro cartilage and lose their round shape, injecting a suspension of autologous cultured chondrocytes into the issue location will not be useful. The best technique to treat osteoarthritis of the knee is to embed chondrocytes in the cartilaginous matrix, which wears away like cartilage.
When chondrocytes are encased in gels, their rounded shape is preserved, and the characteristics of the gels can be adjusted to allow tissue regeneration. The mesh must be tiny enough to retain the cells in place while yet being open enough to allow water and nutrients to pass through. Similarly, the gel structure must breakdown at the proper rate so that the secreted extracellular matrix is not limited to the area surrounding each chondrocyte.
Engineered cartilage tissue can mimic the structural properties of native cartilage to the point where cell orientation and regenerated cartilage resemble genuine cartilage. The cells that are encased in this type of matrix have the ability to move to and from the surface of the cartilage.
One of the most important issues raised by cell-based therapy is how to maximise the utility of cells given to a passive or tolerant environment, where there is context for the type of cell required but few biological signals are produced to support normal cell function. Finally, bioengineers envision a material system in which embedded cells send a signal that causes deeper cells to build bone and surface cells to form cartilage.
Several things are anticipated by regenerative medicine:
-Cell-based therapies are having an increasing impact in clinical medicine.
-Methods for easily regenerating skin, bone, cartilage, bladder, and trachea from bone marrow stem cells, as well as blood arteries and heart valves.
-Restoring function in complicated tissues such as the spinal cord.
-Aiming to regenerate more sophisticated tissues and neo-organs